Bioanalytical / Analytical Chemistry

Our Analytical/Bioanalytical Chemistry Department provides a state-of-the-art infrastructure with experience in chromatography, and mass spectrometry. Lovelace has the experience and tools required to develop, transfer and validate methods on small molecules, proteins or peptides to support PK/TK and metabolism studies.

Analyses can be conducted to assay concentrations of parent molecules or compounds in a full range of matrices including blood, plasma, serum, urine and tissue.

Bioanalytical Chemistry Fact Sheet: Download PDF

Capabilities

  • Parent molecule analysis
  • Metabolism characterization
  • Development/transfer of bioanalytical assays
  • Validation of methods
  • GLP compliance
  • Novel/complex assay development capabilities
    • Multiple analytes
    • Endogenous analytes

Instrumentation

  • Mass spectrometer systems
    • Sciex 5000 – Waters/Shimadzu UPLC
    • Sciex 4500 – Shimadzu UPLC
    • Sciex 4000 – Waters UPLC
  • HPLC
    • Agilent 1100 / 1200; DAD, VWD, RID, FLD detectors
    • UPLC Acquity: PDA, FLD, ECD detectors
  • Gas chromatography
    • Agilent 7980/6980 with MS/FID/ECD/TCD detectors
  • Spectrophotometers
  • Tecan / Eppendorf Liquid Handlers
  • TomTec Quadra Extraction System
  • Molecular Devices and Biotek plate readers
  • Quantitative PCR
  • Planetary Ball Mill
  • Jet Air Mill
  • Solid State Analysis
    • TA Instruments TGA
    • Thermo FTI