Top veterinary talent is at the core of preclinical success. And the more complex the study, the more important that talent becomes. With this as a driving principle, Lovelace has made several key veterinary hires in recent months — growing its expertise for multifaceted studies and ensuring that animals at Lovelace receive the best care possible.
The best-run preclinical research programs are just as devoted to strong science and achieving experimental objectives as they are to adhering to Good Laboratory Practice standards and other essential regulations that govern the industry. After all, without meeting the strict protocols of the FDA, USDA and numerous other oversight organizations, a drug’s preclinical development program is in jeopardy.
Nucleoside analogues are an essential component of many chemotherapies, anti-bacterial drugs and anti-viral agents. These compounds can play a key role in heightening therapeutic effects and, in the case of cancer treatments, leading to cell death.
It may feel like the flu — and be just as grave of a health threat — but it’s not the flu. It’s adenovirus, an infectious disease that often goes undetected because it presents itself almost identically to influenza. Symptoms for both diseases include fever, headache and body aches. Both are highly contagious and spread […]
Increasingly, biopharmaceutical companies are developing nucleoside analogues as chemotherapeutic, anti-bacterial and anti-viral agents.
Of the nucleoside analogues in development, 5-azacytidine is being studied as a targeted therapy for lung cancer, as it may be able to amplify the therapeutic agent at the site of action while reducing off-site toxicities.
Toxicology is often called the “science of safety,” and for good reason. The field is essential in moving potential new drugs from the lab to the clinic, enabling drug sponsors to predict whether any components of the drug may cause harm to patients. And if a chemical is deemed harmful, toxicologists can figure out why.
Innovation is percolating around new approaches to treating injuries that result from chemical, biological, radiological and nuclear defense, as well as other public health emergencies. With funding from BARDA and other government entities, commercial pharmaceutical and biotechnology firms are seeking to repurpose existing molecules to save more lives.
The established cancer drug topotecan may hold promise as a more targeted therapy for patients with small-cell lung cancer (SCLC), according to the results of a study presented by Lovelace Biomedical scientists. The findings are significant, as lung cancer remains one of the leading causes of cancer deaths worldwide. New treatment options are direly needed, […]
For preclinical pharmacology and toxicology studies to succeed, it’s essential that investigators and their teams use best practices for animal enrichment and environmental enhancement. Animal stress — which can stem from lack of trust in the researchers or an inability to express natural, species-specific behaviors — can compromise study data.
Inhaled medicines play an essential role in treating respiratory conditions and many other diseases, from pulmonary fibrosis to asthma. However, a dose of inhaled medicine often results in a cough — an adverse reaction that can be both uncomfortable and counterproductive. It’s a reaction that drug developers seek to avoid as they develop the next […]