Bioanalytical / Analytical Chemistry

Our Analytical/Bioanalytical Chemistry Department provides a state-of-the-art infrastructure with experience in chromatography, mass spectrometry, and immunoaffinity assays. Lovelace has the experience and tools required to develop or transfer methods on small molecules, proteins or peptides to support PK/TK and metabolism studies.

Analyses can be conducted to assay concentrations of parent molecules or compounds in a full range of matrices including blood, plasma, serum, urine and tissue.

Capabilities

  • Parent molecule analysis
  • Metabolism characterization
  • Development/transfer of bioanalytical assays
  • Validation of methods
  • GLP compliance

Instrumentation

  • Mass spectrometer systems
    • API 5000 – Waters UPLC with DAD
    • API 4000 – Waters UPLC
    • API 3600 EP10+ Upgrade – Agilent 1100 LC with DAD
  • Liquid Chromatography
  • HPLC
    • Agilent 1100 / 1200; DAD, VWD, RID, FLD detectors
    • UPLC Acquity PDA; FLD, ECD detectors
  • Gas chromatography
    • Agilent 7980, 6980 and 5980 MS, ECD and FID detectors
  • Spectrophotometers
  • Tecan / Eppendorf Liquid Handlers
  • TomTec Quadra Extraction System
  • Molecular Devices and Biotek plate readers
  • Quantitative PCR
  • Planetary Ball Mill
  • Jet Air Mill
  • Solid State Analysis
    • TA Instruments TGA
    • Thermo FTIR