Publications

2016

Serena Sirigu, James J. Hartman, Vicente José Planelles-Herrero, Virginie Ropars, Sheila Clancy, Xi Wang, Grace Chuang, Xiangping Qian, Pu-Ping Lu, Edward Barrett, Karin Rudolph, Christopher Royer, Bradley P. Morgan, Enrico A. Stura, Fady I. Malik, and Anne M. Houdusse: Highly selective inhibition of myosin motors provides the basis of potential therapeutic application. PNAS 2016 113 (47) E7448-E7455; published ahead of print November 4, 2016, doi:10.1073/pnas.1609342113

Davis PR, Giannini G, Rudolph K, Calloway N, Royer CM, Beckett TL, Murphy MP, Bresch F, Pagani D, Platt T, Wang X, Donovan AS, Sudduth TL, Lou W, Abner E, Kryscio R, Wilcock DM, Barrett EG, Head E.  Aβ vaccination in combination with behavioral enrichment in aged beagles: effects on cognition, Aβ, and microhemorrhages.  Neurobiology of Aging. 2016 Sep 26;49:86-99.

Wang G., Evans C.H., Benson J.M., Hutt L.A., Seagrave J., Wilder J.A., R. Jude Samulski R.J. and Terse P.S. Safety and Biodistribution Assessment of sc-rAAV2.5IL-1Ra Administered via Intra-articular Injection in a Mono-iodoacetate-Induced Osteoarthritis Model in Wistar Rats. Molecular Therapy-Methods & Clinical Development; 3:15052, 2016.

Chand, R., P.J. Kuehl, P.B. Heifetz, H. Moskowitz, J.D. McDonald: Non-clinical Inhalation Delivery of a Biological. In Proceedings of Respiratory Drug Delivery 2016, Vol. 2 (R. N. Dalby, P. R. Byron, J. Peart, J. D. Suman, S. J. Farr and P. M. Young, eds.), pp. 415-418, Virginia Commonwealth University Richmond, VA, 2016.

Tepper, J.S., P.J. Kuehl, S. Cracknell, K.J. Nikula, L. Pei and J.D. Blanchard: Symposium Summary: “Breathe In, Breathe Out, It’s Easy: What You Need to Know about Developing Inhaled Drugs”. International Journal of Toxicology. Ahead of print. 1-17, 2016.

Kuehl, P. J., E.G. Barrett, M. Burke, R. Chand, D. DuBose, B. Moeller, K. Rudolph, R. Sheeler, and D. Vodak: Is Systemic PK Really an Indicator of Pulmonary Deposition? A Fluticasone Propionate Case Study. In Proceedings of Respiratory Drug Delivery 2016, Vol. 1 (R. N. Dalby, P. R. Byron, J. Peart, J. D. Suman, S. J. Farr and P. M. Young, eds.), pp. 55-62, Virginia Commonwealth University Richmond, VA, 2016.

Leach, C.L., R. Chand, P.J. Kuehl: Human Clinical Nasal Deposition and Retention from Nonaqueous and Aqueous Steroid Inhalers. In Proceedings of Respiratory Drug Delivery 2016, Vol. 1 (R. N. Dalby, P. R. Byron, J. Peart, J. D. Suman, S. J. Farr and P. M. Young, eds.), pp. 193-202, Virginia Commonwealth University Richmond, VA, 2016.

Leach, C.L., P.J. Kuehl, R. Chand, J.D. McDonald: Respiratory tract deposition of HFA-beclomethasone and HFA-fluticasone in asthmatic patients. Aerosol Medicine and Pulmonary Drug Delivery. 29(2), 127-133, 2016.

Hastedt, J.E., P. Bäckman, A. R. Clark, W. Doub, A. Hickey, G. Hochhaus, P. J. Kuehl, Claus-Michael Lehr, P. Mauser, J. McConville, R. Niven, M. Sakagimi, and J. G. Weers: Scope and Relevance of a Pulmonary Biopharmaceutical Classification System – Summary of an AAPS/FDA/USP Workshop Held March 16-17th, 2015 in Baltimore, MD. AAPS Open. 2:1, 2016.

2015

Corti M, Cleaver B, Clément N, Conlon TJ, Faris KJ, Wang G, Benson J, Tarantal AF, Fuller D, Herzog RW, Byrne BJ. Evaluation of Readministration of a Recombinant Adeno-Associated Virus Vector Expressing Acid Alpha-Glucosidase in Pompe Disease: Preclinical to Clinical Planning. Hum Gene Ther Clin Dev.;26(3):185-93, 2015.

Barrett EG, K. Rudolph, C. Royer, G. Dietsch, and R. Hershberg.  VTX-378, A Novel TLR-8 Agonist, Attenuates Nasal Congestion after Ragweed Challenge in Sensitized Beagle Dogs Immun Inflamm Dis. 2015 Dec 7;4(1):45-51.

Kuehl, P.J., T. Boyden, M. Doyle-Eisele, B. G. Murri, D. E. Dobry, D. T. Friesen,   Vodak, D. T., and D. K. Lyon: Inhaled PYY(3-36) Dry Powder Formulation for Appetite Drug Dev Ind Pharm. 26: 1-7, 2015.

Filipczak, P., A. Senft, J. Seagrave, W. Weber, P.J. Kuehl, L. Fredenburgh, J. D. McDonald, and R. Baron.  NOS-2 Inhibition in Phosgene-Inducted Acute Lung Injury.  Toxicol Sci. 146(1): 89-100, 2015.

Reed, M., J. Wilder, W. Mega. P.J. Kuehl, M. Valderas, L. Chew, B. Liang, and C. Squires: Immunization with a Recombinant, Mutant Form of Bacillus anthracis-derived Protective Antigen Protects Rabbits from Anthrax Infection.  PLOS ONE. DOI:10.1371/journal.pone.0130952, 2015.

Leach, C.L., P.J. Kuehl, R. Chand, J.D. McDonald: Respiratory tract deposition of HFA-beclomethasone and HFA-fluticasone in asthmatic patients.  J. Aerosol Medicine and Pulmonary Drug Delivery. 25, 2015.

Kuehl PJ, Boyden T, Dobry DE, Doyle-Eisele M, Friesen DT, McDonald JD, et al. Inhaled PYY(3-36) dry-powder formulation for appetite suppression. Drug Dev Ind Pharm [Internet]. 2015 May 26 [cited 2015 Jun 8];1–7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26006332

Leach CL, Kuehl PJ, Chand R, McDonald JD. Nasal Deposition of HFA-Beclomethasone, Aqueous Fluticasone Propionate and Aqueous Mometasone Furoate in Allergic Rhinitis Patients. J Aerosol Med Pulm Drug Deliv [Internet]. 2015 Feb 11 [cited 2015 Mar 9]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/25671692

Leach CL, Kuehl PJ, Chand R, McDonald JD. Respiratory Tract Deposition of HFA-Beclomethasone and HFA-Fluticasone in Asthmatic Patients. J Aerosol Med Pulm Drug Deliv [Internet]. 2015 Jun 10 [cited 2015 Jul 10]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/26061801

2014

Davis LE, Koster FT, Cawthon A. Neurologic aspects of influenza viruses. Handb Clin Neurol [Internet]. 2014 Jan [cited 2014 Aug 6];123:619–45. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25015508

Doyle-Eisele ML, Weber WM, Melo DR, Guilmette RA. Whole-body distribution of americium in rats for different pathways of intake. Int J Radiat Biol [Internet]. 2014 Nov [cited 2015 Jan 5];90(11):1068–74. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24844378

Mauderly JL, Barrett EG, Day KC, Gigliotti AP, McDonald JD, Harrod KS, et al. The National Environmental Respiratory Center (NERC) experiment in multi-pollutant air quality health research: II. Comparison of responses to diesel and gasoline engine exhausts, hardwood smoke and simulated downwind coal emissions. Inhal Toxicol [Internet]. 2014 Sep [cited 2014 Sep 9];26(11):651–67. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25162719

Mauderly JL, Kracko DA, Brower J, Doyle-Eisele ML, McDonald JD, Lund AK, et al. The National Environmental Respiratory Center (NERC) experiment in multi-pollutant air quality health research: IV. Vascular effects of repeated inhalation exposure to a mixture of five inorganic gases. Inhal Toxicol [Internet]. 2014 Sep [cited 2014 Sep 9];26(11):691–6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25162721

McDonald JD, Kracko DA, Doyle-Eisele ML, Garner CE, Wegerski CJ, Senft AP, et al. Carbon Capture and Sequestration: An Exploratory Inhalation Toxicity Assessment of Amine-Trapping Solvents and Their Degradation Products. Environ Sci Technol [Internet]. 2014 Aug 28 [cited 2014 Sep 9]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/25167095

Melo DR, Weber WM, Doyle-Eisele ML, Guilmette RA. Comparison of plutonium systemic distribution in rats and dogs with published data in humans. Int J Radiat Biol [Internet]. 2014 Nov [cited 2015 Jan 5];90(11):1025–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24669776

Polverino F, Doyle-Eisele ML, McDonald JD, Wilder JA, Royer CM, Laucho-Contreras ME, et al. A Novel Nonhuman Primate Model of Cigarette Smoke-Induced Airway Disease. Am J Pathol [Internet]. 2014 Dec 23 [cited 2015 Jan 5]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/25542772

Weber WM, Doyle-Eisele ML, Melo DR, Guilmette RA. Whole-body distribution of plutonium in rats for different routes of exposure. Int J Radiat Biol [Internet]. 2014 Nov [cited 2015 Jan 5];90(11):1011–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24552148

Barrett EG, Royer CM, Nicodem J, Gaskins G, Gianinni G, Wilder JA, et al. Viral exacerbation is associated with steroid insensitive neutrophilia, ILC2s, and AHR in HDM-sensitized BALB/c mice. American Thoracic Society Annual Conference. San Diego, CA; 2014.

Clay CC, Donart N, Fomukong N, Knight JB, Overheim KA, Tipper JL, et al. Severe acute respiratory syndrome-coronavirus infection in aged nonhuman primates is associated with modulated pulmonary and systemic immune responses. Immun Ageing [Internet]. 2014 Jan [cited 2014 Apr 7];11(1):4. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24642138

Doyle-Eisele ML, Rohr AC, Knipping EM, Lund AK, Brower J, McDonald JD. Secondary Organic Aerosols Generated from α-Pinene-Amine Mixtures: Effects on the Cardiovascular System. Society of Toxicology. Phoenix, AZ; 2014.

Gundavarapu S, Zhuang J, Barrett EG, Xu F, Russell RG, Sopori ML. A critical role of acute bronchoconstriction in the mortality associated with high-dose sarin inhalation: effects of epinephrine and oxygen therapies. Toxicol Appl Pharmacol [Internet]. 2014 Jan 15 [cited 2014 Apr 7];274(2):200–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24269878

Holmes TD, McDonald JD, Kuehl PJ, Kracko DA. Characterization of the Blu e-cigarette to define the composition of inhaled material. Society of Toxicology. Phoenix, AZ; 2014.

Kracko DA, Wegerski CJ, McDonald JD, Doyle-Eisele ML, Shaw S, Knipping EM, et al. Pulmonary Toxicity of Oxygen and Carbon Dioxide Degraded Amines Used for Carbon Capture and Storage. Society of Toxicology. Phoenix, AZ; 2014.

Kuehl PJ, Chand R, McDonald JD, Leach CL. Pulmonary deposition of FP/SX, FP and BCP – HFA pMDI’s via SPECT/CT imaging. Respiratory Drug Delivery2. Fajardo, Puerto Rico; 2014.

McDonald JD, Mauderly JL, Miller RA, Seilkop SK, Seagrave JC, Gigliotti AP, et al. ACES Phase 3: Results from lifetime studies in rats exposed to 2007 compliant diesel emissions. Society of Toxicology. Phoenix, AZ; 2014.

Wang, G., Young, S.P, Bali, D., Hutt, J., Songtao, L., Benson, J., and Koeberll, D.  Assessment of the Toxicity and Biodistribution of Recombinant AAV8vector-mediated Immunomodulatory Gene Therapy in Mice with Pompe Disease.  Molecular Therap – Methods and Clinical Development 2014 1, 14018;doi:1038/mtm.2014.18.

Salmon, M., S. Tannheimer, T. Gentzler, Z.H. Cui, E. Sorensen, K. Hartsough, M. Kim, L. Purvis, E. Barrett, J. McDonald, K. Rudolph, M. Doyle-Eisele, P.J. Kuehl, C. Royer ,W. Baker, G. Phillips, and C. Wright: The In Vivo Efficacy and Side-Effect Pharmacology of GS-5759, A Novel Bifunctional Phosphodiesterase 4 Inhibitor and Long-Acting β2-Adrenoceptor Agonist in Pre-Clinical Animal Species. Pharmacology and Research Perspectives. DOI: 2(4): 1-12, 2014.

Kuehl, P.J., A. Cherrington, D.E. Dobry, D. Egerton, D.T. Friesen, C. Hobbs, C. L. Leach, B. Murri, D. Neal, D.K. Lyon and D. T. Vodak: Biological Comparison of Inhaled Insulin Formulations: Exubera™ and Novel Spray-Dried Engineered Particles of Dextran-10. AAPS PharmSciTech. 15(6): 1545-1550, 2014.

2013

Lund AK, Doyle-Eisele ML, Lin Y-H, Arashiro M, Surratt JD, Holmes TD, et al. The effects of α-pinene versus toluene-derived secondary organic aerosol exposure on the expression of markers associated with vascular disease. Inhal Toxicol [Internet]. 2013 May [cited 2013 Sep 19];25(6):309–24. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23742109

McDonald JD, Chow JC, Peccia J, Liu Y, Chand R, Hidy GM, et al. Influence of collection region and site type on the composition of paved road dust. Air Qual Atmos Heal. 2013;6(3):615–28.

Oppenheim HA, Lucero J, Guyot A-C, Herbert LM, McDonald JD, Mabondzo A, et al. Exposure to vehicle emissions results in altered blood brain barrier permeability and expression of matrix metalloproteinases and tight junction proteins in mice. Part Fibre Toxicol [Internet]. 2013 Jan [cited 2013 Dec 21];10(1):62. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3878624&tool=pmcentrez&rendertype=abstract

Reed MD, Tellez CS, Grimes MJ, Picchi MA, Tessema M, Cheng YS, et al. Aerosolised 5-azacytidine suppresses tumour growth and reprogrammes the epigenome in an orthotopic lung cancer model. Br J Cancer [Internet]. 2013 Oct 1 [cited 2013 Nov 21];109(7):1775–81. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24045660

Royer CM, Rudolph K, Barrett EG. The neonatal susceptibility window for inhalant allergen sensitization in the atopically predisposed canine asthma model. Immunology [Internet]. 2013 Apr [cited 2013 Sep 23];138(4):361–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23181409

Vedal S, Campen MJ, McDonald JD, Larson T V, Sampson PD, Sheppard L, et al. National Particle Component Toxicity (NPACT) initiative report on cardiovascular effects. Res Rep Health Eff Inst [Internet]. 2013 Oct [cited 2014 Jan 6];(178):5–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24377210

Chiuchiolo, M.J., Kaminsky, S.M., Sondhi, D., Hackett, N.R., Rosenberg, J.B. Frenk, e.Z. Hwant, Y. Vand de Graff, B.G., Hutt, J.A., Wang, G., Benson, J. and Crystal R.G.  Intrapleaural  Administration of an AAAVrh.10 Vector Coding for Human α1-antitrypsin for the Treatment of α1-antitrypsi Deficiency.  Human Gene Ther Clin Dev, 24(4): 161-173, 2013.

McDonald, C.L., Benson, J., Cornetta, K., Diggins, M., Johnston, J.C., Sepelak, S., Wang, G., Wright, J.F., Skarlatos, S.I.  Advancing Translational Research Through the NHLBI Gene Therapy Resource Program (GTRP).  Human Gene Ther Clin Dev 24(1): 5 – 10, 2013.

Reed, M.D., C. S. Tellez, M. J. Grimes, M. A Picchi, M. Tessema, Y. S. Cheng, T. H. March, P. J. Kuehl and S. A. Belinsky: Aerosolized Vidaza Suppresses Tumor Growth and Reprograms the Epigenome in an Orthotropic Lung Cancer Model.  British Journal of Cancer. 109: 1775-1781, 2013.

2012

Corcoran TE, Devadason SG, Kuehl PJ. Introduction: Aerosol delivery of orally inhaled agents. J Aerosol Med Pulm Drug Deliv [Internet]. 2012 Dec [cited 2014 Feb 18];25 Suppl 1:S3–5. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23215846

Kreider ML, Doyle-Eisele ML, Russell RG, McDonald JD, Panko JM. Evaluation of potential for toxicity from subacute inhalation of tire and road wear particles in rats. Inhal Toxicol [Internet]. 2012 Nov [cited 2014 Feb 17];24(13):907–17. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23121300

Kuehl PJ, Anderson TL, Candelaria G, Gershman B, Harlin K, Hesterman JY, et al. Regional particle size dependent deposition of inhaled aerosols in rats and mice. Inhal Toxicol [Internet]. 2012 Jan [cited 2013 Sep 24];24(1):27–35. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22145784

Kuehl PJ, De S, Eppler B, Marsters J, Matthews L, Reed MD, et al. Development and validation of an HPLC assay for dual detection of gentamicin sulfate and leucine from a novel dry powder for inhalation. J Anal Bioanal Tech. 2012;3(6):1–4.

Leach CL, Kuehl PJ, Chand R, Ketai L, Norenberg JP, McDonald JD. Characterization of respiratory deposition of fluticasone-salmeterol hydrofluoroalkane-134a and hydrofluoroalkane-134a beclomethasone in asthmatic patients. Ann Allergy Asthma Immunol [Internet]. 2012 Mar [cited 2013 Sep 24];108(3):195–200. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22374204

McDonald JD, Doyle-Eisele ML, Gigliotti AP, Miller RA, Seilkop SK, Mauderly JL, et al. Part 1. Biologic responses in rats and mice to subchronic inhalation of diesel exhaust from U.S. 2007-compliant engines: report on 1-, 3-, and 12-month exposures in the ACES bioassay. Res Rep Health Eff Inst [Internet]. 2012 Sep [cited 2013 Sep 24];(166):9–120. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23156840

McDonald JD, Doyle-Eisele ML, Kracko DA, Lund AK, Surratt JD, Hersey SP, et al. Cardiopulmonary response to inhalation of secondary organic aerosol derived from gas-phase oxidation of toluene. Inhal Toxicol [Internet]. 2012 Sep [cited 2013 Sep 17];24(11):689–97. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22954394

McDonald JD, White RK, Holmes TD, Mauderly JL, Zielinska B, Chow JC. Simulated downwind coal combustion emissions for laboratory inhalation exposure atmospheres. Inhal Toxicol [Internet]. 2012 Apr [cited 2013 Sep 24];24(5):310–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22486348

Reed MD, McCombie BE, Sivillo AE, Thorne PS, Welsh MJ, March TH, et al. Safety assessment of nebulized xylitol in beagle dogs. Inhal Toxicol [Internet]. 2012 May [cited 2013 Sep 24];24(6):365–72. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22564094

Weber WM, Doyle-Eisele ML, Seilkop SK, Guilmette RA. Biokinetics of systemically distributed 60Co in the rat: an experimental model useful in evaluating medical countermeasures for internal contamination. Health Phys [Internet]. 2012 Oct [cited 2013 Sep 24];103(4):474–83. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22929473

Garcia, A., P. Mack, S. Williams, C. Fromen, T. Shen, J. Pillai, P. J. Kuehl, M. Napier, J. M. Desimon and B. W. Maynor: Microfabricated Engineered Particle Systems for Respiratory Drug Delivery and other Pharmaceutical Applications. Drug Delivery. Article ID 941243, 2012.

Breit, J., P. J. Kuehl, and W. Schachtner: Development of Inhalable Dry-Powder Formulations for Low Water-Soluble Products using Spray-Dried Engineered Particles. Inhalation Magazine 6(2): 19-23, 2012.

Breit, J., D. Vodak, P. J. Kuehl, M. Doyle-Eisele, M. Reed, and B. Schachtner: Pharmacokinetic Analysis of an Inhalable Spray-Dried Engineered Particle Formulation of Camptothecin for the Treatment of Lung Cancer. In Proceedings of Respiratory Drug Delivery 2012, Vol. 2 (R. N. Dalby, P. R. Byron, J. Peart, J. D. Suman, S. J. Farr and P. M. Young, eds.), pp. 407-412, Virginia Commonwealth University Richmond, VA, 2012.

Chand, R., P. J. Kuehl, C. Leach, and J. D. McDonald: Radiolabeling Validation of Fluticasone Propionate/Salmeterol Xinafoate – HFA Pressurized Metered Dose Inhaler. In Proceedings of Respiratory Drug Delivery 2012, Vol. 2 (R. N. Dalby, P. R. Byron, J. Peart, J. D. Suman, S. J. Farr and P. M. Young, eds.), pp. 573-576, Virginia Commonwealth University Richmond, VA, 2012.

Devadason, S. G., H. K. Chan, S. Haussermann, C. Kietzig, P. J. Kuehl, S. Newman, K. Sommerer, and G. Taylor: Standardization of Techniques for Validation of Radiolabeling of Drug Formulations for Aerosol Deposition Assessment of Orally Inhaled Products. Aerosol Med. Pulm. Drug Deliv. 25: S6-S9, 2012.

Newman, S., W. D. Bennett, M. Biddiscombe, S. G. Devadason, M. Dolovich, J. Fleming, S. Haeussermann, C. Kietzig, P. J. Kuehl, B. L. Laube, K. Sommerer, G. Taylor, O. S. Usmani, and K. L. Zeman: Standarization of Techniques for Using Planar (2D) Imaging for Aerosol Deposition Assessment of Orally Inhaled Products. Aerosol Med. Pulm. Drug Deliv. 25: S-10-S28, 2012.

Fleming, J., D. Bailey, H. K. Chan, J. Conway, P. J. Kuehl, B. L. Laube and S. Newman: Standardization of Techniques for Using Single-Photon Emission Computed Tomography (SPECT) for Aerosol Deposition Assessment of Orally Inhaled Products. Aerosol Med. Pulm. Drug Deliv. 25: S29-S51, 2012.

2011

Barrett EG, Day KC, Gigliotti AP, Reed MD, McDonald JD, Mauderly JL, et al. Effects of simulated downwind coal combustion emissions on pre-existing allergic airway responses in mice. Inhal Toxicol [Internet]. 2011 Nov [cited 2013 Sep 24];23(13):792–804. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22035121

Benson JM, Gomez AP, Wolf ML, Tibbetts BM, March TH. The acute toxicity, tissue distribution, and histopathology of inhaled ricin in Sprague Dawley rats and BALB/c mice. Inhal Toxicol [Internet]. 2011 Apr [cited 2013 Sep 24];23(5):247–56. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21473711

Benson JM, Seagrave JC, Weber WM, Santistevan CD, Grotendorst GR, Schultz GS, et al. Time course of lesion development in the hairless guinea-pig model of sulfur mustard-induced dermal injury. Wound Repair Regen [Internet]. 2011 [cited 2013 Sep 24];19(3):348–57. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3650627&tool=pmcentrez&rendertype=abstract

Benson JM, Tibbetts BM, Weber WM, Grotendorst GR. Uptake, tissue distribution, and excretion of 14C-sulfur mustard vapor following inhalation in F344 rats and cutaneous exposure in hairless guinea pigs. J Toxicol Environ Health A [Internet]. 2011 Jan [cited 2013 Sep 24];74(13):875–85. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21598172

Benson JM, Wolf ML, Kajon AE, Tibbetts BM, Bourdelais AJ, Baden DG, et al. Brevetoxin inhalation alters the pulmonary response to influenza A in the male F344 rat. J Toxicol Environ Health A [Internet]. 2011 Jan [cited 2013 Sep 24];74(5):313–24. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3444170&tool=pmcentrez&rendertype=abstract

Kuehl PJ. Imaging pulmonary drug delivery. In: Smyth HDC, Hickey A, editors. Controlled Pulmonary Drug Delivery. New York, NY: Springer; 2011. p. 475–87.

Lu K, Moeller BC, Doyle-Eisele ML, McDonald JD, Swenberg JA. Molecular dosimetry of N2-hydroxymethyl-dG DNA adducts in rats exposed to formaldehyde. Chem Res Toxicol [Internet]. 2011 Feb 18 [cited 2013 Sep 24];24(2):159–61. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3128468&tool=pmcentrez&rendertype=abstract

Lund AK, Lucero J, Harman M, Madden MC, McDonald JD, Seagrave JC, et al. The oxidized low-density lipoprotein receptor mediates vascular effects of inhaled vehicle emissions. Am J Respir Crit Care Med [Internet]. 2011 Jul 1 [cited 2013 Sep 24];184(1):82–91. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3172889&tool=pmcentrez&rendertype=abstract

Maresh JG, Campen MJ, Reed MD, Darrow AL, Shohet R V. Hypercholesterolemia potentiates aortic endothelial response to inhaled diesel exhaust. Inhal Toxicol [Internet]. 2011 Jan [cited 2013 Sep 24];23(1):1–10. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3606052&tool=pmcentrez&rendertype=abstract

Mauderly JL, Barrett EG, Gigliotti AP, McDonald JD, Reed MD, Seagrave JC, et al. Health effects of subchronic inhalation exposure to simulated downwind coal combustion emissions. Inhal Toxicol [Internet]. 2011 May [cited 2013 Sep 24];23(6):349–62. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21605010

McDonald JD, Campen MJ, Harrod KS, Seagrave JC, Seilkop SK, Mauderly JL. Engine-operating load influences diesel exhaust composition and cardiopulmonary and immune responses. Environ Health Perspect [Internet]. 2011 Aug [cited 2013 Sep 24];119(8):1136–41. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3237353&tool=pmcentrez&rendertype=abstract

Moeller BC, Lu K, Doyle-Eisele ML, McDonald JD, Gigliotti AP, Swenberg JA. Determination of N2-hydroxymethyl-dG adducts in the nasal epithelium and bone marrow of nonhuman primates following 13CD2-formaldehyde inhalation exposure. Chem Res Toxicol [Internet]. 2011 Feb 18 [cited 2013 Sep 24];24(2):162–4. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3273041&tool=pmcentrez&rendertype=abstract

Smith KR, Leonard D, McDonald JD, Tesfaigzi Y. Inflammation, mucous cell metaplasia, and Bcl-2 expression in response to inhaled lipopolysaccharide aerosol and effect of rolipram. Toxicol Appl Pharmacol [Internet]. 2011 Jun 15 [cited 2013 Sep 24];253(3):253–60. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3103593&tool=pmcentrez&rendertype=abstract

Vodak D, Dobry D, Friesen DT, Reed MD, Gigliotti AP, Kuehl PJ, et al. Dextran-based materials as excipients in engineered particle formulations: tailoring physical properties to optimize performance, manufacturability, and safety. In: Dalby RN, Byron PR, Peart J, Suman JD, Farr SJ, Yound PM, editors. Proceedings of Respiratory Drug Delivery. Richmond VA: Virginia Commonwealth University; 2011. p. 1–9.

Weber WM, Kracko DA, Lehman MR, Cox CE, Cheng YS, Grotendorst GR, et al. Dermal and ocular exposure systems for the development of models of sulfur mustard-induced injury. Toxicol Mech Methods [Internet]. 2011 Sep [cited 2013 Sep 27];21(7):547–53. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21473735

Chulay J.D. Ye, G.J., Thomas, D.L., Knop, D.R. Benson, J.M., Hutt, J.A., Wang, G, Humphries, M., Flotte, T.R. Preclinical Evaluation of a Recombinant Adeno-associated virus Vector Expressing Human alpha-1 antitrypsin Made Using a recombinant  Herpes Simplex Virus Production Method.  Hum Gene Ther.  22(2) 155-165, 2011.

Feng, A. L., M. A. Boraey, M. A., Gwin, P. R. Finlay, P. J. Kuehl and R. Vehring. Mechanistic Models Facilitate Efficient Development of Leucine Containing Microparticles for Pulmonary Drug Delivery. J. Pharm. 409 (1-2): 156-163, 2011.

2010

Aillon KL, El-Gendy N, Dennis C, Norenberg JP, McDonald JD, Berkland C. Iodinated NanoClusters as an inhaled computed tomography contrast agent for lung visualization.Mol Pharm [Internet]. 2010 Aug 2 [cited 2014 Feb 20];7(4):1274–82. Available from:http://www.ncbi.nlm.nih.gov/pubmed/20575527

Kuehl PJ, Barrett EG, McDonald JD, Rudolph K, Vodak D, Dobry D, et al. Formulation development and in vivo evaluation of a new dry powder formulation of albuterol sulphate in beagle dogs. Pharm Res [Internet]. 2010 May [cited 2013 Sep 30];27(5):894–904. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20232119

Kuehl PJ, Belinsky SA, Chand R, Channell MM, Lucak J, McDonald JD, et al. Pharmacokinetic comparison and analysis of aqueous and dry powder inhalation formulations of 5-azacytidine. In: Dalby R, Byron P, Peart J, Suman J, Farr S, Young P, editors. Proceedings of Respiratory Drug Delivery, Vol 2. Richmond VA: Virginia Commonwealth University; 2010. p. 627–31.

McDonald JD, Doyle-Eisele ML, Campen MJ, Seagrave JC, Holmes TD, Lund AK, et al. Cardiopulmonary response to inhalation of biogenic secondary organic aerosol. Inhal Toxicol [Internet]. 2010 Mar [cited 2013 Sep 30];22(3):253–65. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20148748

Vodak D, Dobry D, Kuehl PJ, Barrett EG, Rudolph K, McDonald JD, et al. Assessment of lung function in a ragweed challenge dog model after inhalation of engineered particle formulation of albuterol sulfate. In: Dalby R, Byron P, Peart J, Suman J, Farr S, Young P, editors. Proceedings of Respiratory Drug Delivery, Vol 22. Richmond VA: Virginia Commonwealth University; 2010. p. 431–4.

Weber WM, Kracko DA, Lehman MR, Irvin CM, Blair LF, White RK, et al. Inhalation exposure systems for the development of rodent models of sulfur mustard-induced pulmonary injury. Toxicol Mech Methods [Internet]. 2010 Jan [cited 2013 Sep 30];20(1):14–24. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3154732&tool=pmcentrez&rendertype=abstract

Talton, J. T., B. Eppler, J. F. Kirk, B. E. Hammoud, L. Matthews, N. Dungan, C. Waters, R. Casper, E. Richardson, J. Suman, S. De, M. D. Reed, E. Barr, P. J. Kuehl, M. Doyle-Eisele, M. Valderas, C. Roy and D. Gardner: Inhaled Gentamicin: Making a Dry Powder Formulation to Satisfy a Clinical Need. In Proceedings of Respiratory Drug Delivery 2010, 2 (R. N. Dalby, P. R. Byron, J. Peart, J. D. Suman, S. J. Farr and P. M. Young, eds.), pp. 63-72, Virginia Commonwealth University, Richmond, VA, 2010.

2009

Kuehl PJ, Stratton SP, Powell MB, Myrdal PB. Preformulation, formulation, and in vivo efficacy of topically applied apomine. Int J Pharm [Internet]. 2009 Dec 1 [cited 2013 Oct 1];382(1-2):104–10. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2783960&tool=pmcentrez&rendertype=abstract

Mitchell LA, Lauer FT, Burchiel SW, McDonald JD. Mechanisms for how inhaled multiwalled carbon nanotubes suppress systemic immune function in mice. Nat Nanotechnol [Internet]. 2009 Jul [cited 2013 Oct 7];4(7):451–6. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3641180&tool=pmcentrez&rendertype=abstract

Vodak, D. T., D. E. Dobry, P. J. Kuehl, M. Doyle-Eisele, J. D. McDonald, A. Silcock, G. Magee, D. Pole, W. K. Miller, D. Friesen and D. K. Lyon:  Platform Formulation Development Utilizing a Novel Pulmonary Excipient and In Vivo Evaluation of Engineered Particles of Fluticasone Propionate as a Model Formulation.  In Proceedings of Respiratory Drug Delivery 2009, Vol. 2 (R. N. Dalby, P. R. Byron, J. Peart, J. D. Suman, S. J. Farr and P. M. Young, eds.), pp. 251-254, Virginia Commonwealth University, Richmond, VA, 2009.

Kuehl, P.: RMV Data Analysis and Conclusions by AIT Working Party. Inhal. Toxicol. 21(5): 434, 2009.

2008

Barrett EG. Maternal influence in the transmission of asthma susceptibility. Pulm Pharmacol Ther [Internet]. 2008 Jan [cited 2013 Oct 11];21(3):474–84. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2478516&tool=pmcentrez&rendertype=abstract

Day KC, Reed MD, McDonald JD, Seilkop SK, Barrett EG. Effects of gasoline engine emissions on preexisting allergic airway responses in mice. Inhal Toxicol [Internet]. 2008 Oct [cited 2013 Oct 11];20(13):1145–55. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18951231

Kuehl PJ, Brenner T, Jain PK, Karlage K, Sepassi K, Yang G, et al. Formulation and in vivo evaluation of chlorpropham (CIPC) oral formulations. J Pharm Sci [Internet]. 2008 Dec [cited 2013 Oct 11];97(12):5222–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18383335

Kuehl PJ, Cheng YS, Holmes TD, Irshad H, Leach CL, McDonald JD. Regional deposition analysis of a Technetium-99m labeled aerosol to anesthetized non human primates by planar gamma camera imaging. In: Dalby R, Byron P, Peart J, Suman J, Farr S, Young P, editors. Proceedings of Respiratory Drug Delivery Vol 2. Richmond VA: Virginia Commonwealth University; 2008. p. 601–4.

Kuehl PJ, Karlage K, Brenner T, Myrdal PB. Determining the effect of Carbendazim and Paclitaxel, dosed orally and via inhalation, on pulmonary adenomas in the A/J mouse model. In: Dalby R, Byron P, Peart J, Suman J, Farr S, Young P, editors. Proceedings of Respiratory Drug Delivery Vol 2. Richmond VA: Virginia Commonwealth University; 2008. p. 605–10.

McDonald JD, Barr EB, White RK, Kracko DA, Chow JC, Zielinska B, et al. Generation and characterization of gasoline engine exhaust inhalation exposure atmospheres. Inhal Toxicol [Internet]. 2008 Oct [cited 2013 Oct 14];20(13):1157–68. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18951232

Reed MD, Barrett EG, Campen MJ, Divine KK, Gigliotti AP, McDonald JD, et al. Health effects of subchronic inhalation exposure to gasoline engine exhaust. Inhal Toxicol [Internet]. 2008 Oct [cited 2013 Oct 14];20(13):1125–43. Available from: http://www.ncbi.nlm.nih.gov/pubmed/1880

Seagrave JC, Campen MJ, McDonald JD, Mauderly JL, Rohr AC. Oxidative stress, inflammation, and pulmonary function assessment in rats exposed to laboratory-generated pollutant mixtures. J Toxicol Environ Health A [Internet]. 2008 Jan [cited 2013 Oct 14];71(20):1352–62. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18704828

Weber WM, Marr R, Kracko DA, Gao Z, McDonald JD, Chearnaigh KU. Disposition of tungsten in rodents after repeat oral and drinking water exposures. Toxciology Environ Chem. 2008;90(3):445–55.

Xu J, Xu F, Barrett EG. Metalloelastase in lungs and alveolar macrophages is modulated by extracellular substance P in mice. Am J Physiol Lung Cell Mol Physiol [Internet]. 2008 Jul [cited 2013 Oct 14];295(1):L162–70. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2494786&tool=pmcentrez&rendertype=abstract

Cheng, Y. S., H. Irshad, P. Kuehl, T. D. Holmes, R. Sherwood and C. H. Hobbs: Lung Deposition of Droplet Aerosols in Monkeys.  Toxicol. 20(11): 1029-1036, 2008.

2007

Leach CL. Inhalation aspects of therapeutic aerosols. Toxicol Pathol [Internet]. 2007 Jan [cited 2013 Oct 14];35(1):23–6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17325969

McDonald JD, Weber WM, Marr R, Kracko DA, Khain H, Arimoto R. Disposition and clearance of tungsten after single-dose oral and intravenous exposure in rodents. J Toxicol Environ Health A [Internet]. 2007 May 15 [cited 2013 Oct 14];70(10):829–36. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17454559

Mogalian, E., P. J. Kuehl and P. B. Myrdal: New Analytical Techniques to Facilitate Preformulation Screening in Propellant Systems.  J. Pharm. 340(1-2): 223-229, 2007.

Myrdal, P. B., K. Karlage, P. J. Kuehl, B. S. Angersbach, B. A. Merrill and P. D. Wightman: Effects of Novel 5-Lipoxygenase Inhibitors on the Incidence of Pulmonary Adenomas in the A/J Murine Model when Administered via Nose-Only Inhalation.  Carcinogenesis 28(5): 957-961, 2007.

2006

Barrett EG, Henson RD, Seilkop SK, McDonald JD, Reed MD. Effects of hardwood smoke exposure on allergic airway inflammation in mice. Inhal Toxicol [Internet]. 2006 Jan [cited 2013 Oct 18];18(1):33–43. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16326399

Benson JM, Gomez AP, Statom GL, Tibbetts BM, Fleming LE, Backer LC, et al. Placental transport of brevetoxin-3 in CD-1 mice. Toxicon [Internet]. 2006 Dec 15 [cited 2013 Oct 21];48(8):1018–26. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2561222&tool=pmcentrez&rendertype=abstract

Campen MJ, McDonald JD, Reed MD, Seagrave JC. Fresh gasoline emissions, not paved road dust, alter cardiac repolarization in ApoE-/- mice. Cardiovasc Toxicol [Internet]. 2006 Jan [cited 2013 Oct 21];6(3-4):199–210. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17347530

Head E, Barrett EG, Murphy MP, Das P, Nistor M, Sarsoza F, et al. Immunization with fibrillar Abeta(1-42) in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Abeta. Vaccine [Internet]. 2006 Apr 5 [cited 2013 Oct 21];24(15):2824–34. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16460841

McDonald JD, White RK, Barr EB, Zielinska B, Chow JC, Grosjean E. Generation and characterization of hardwood smoke inhalation exposure atmospheres. Aerosol Sci Technol. 2006;40(8):573–84.

Phaybouth V, Wang S-Z, Hutt JA, McDonald JD, Harrod KS, Barrett EG. Cigarette smoke suppresses Th1 cytokine production and increases RSV expression in a neonatal model. Am J Physiol Lung Cell Mol Physiol [Internet]. 2006 Feb [cited 2013 Oct 24];290(2):L222–31. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16126789

Reed MD, Blair LF, Burling K, Daly I, Gigliotti AP, Gudi R, et al. Health effects of subchronic exposure to diesel-water-methanol emulsion emission. Toxicol Ind Health [Internet]. 2006 Mar [cited 2013 Oct 24];22(2):65–85. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16716037

Reed MD, Campen MJ, Gigliotti AP, Harrod KS, McDonald JD, Seagrave JC, et al. Health effects of subchronic exposure to environmental levels of hardwood smoke. Inhal Toxicol [Internet]. 2006 Jul [cited 2013 Oct 24];18(8):523–39. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16717024

Seagrave JC, McDonald JD, Bedrick EJ, Edgerton ES, Gigliotti AP, Jansen JJ, et al. Lung toxicity of ambient particulate matter from southeastern U.S. sites with different contributing sources: relationships between composition and effects. Environ Health Perspect [Internet]. 2006 Sep [cited 2013 Oct 24];114(9):1387–93. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1570075&tool=pmcentrez&rendertype=abstract

Yan X, Benson JM, Gomez AP, Baden DG, Murray TF. Brevetoxin-induced neural insult in the retrosplenial cortex of mouse brain. Inhal Toxicol [Internet]. 2006 Dec [cited 2013 Oct 24];18(14):1109–16. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2613569&tool=pmcentrez&rendertype=abstract

Kuehl, P., B. S. Angersbach, S. P. Stratton and P. B. Myrdal: Development of an HPLC Method for the Analysis of Apomine in a Topical Cream Formulation.   Pharm. Biomed. Anal. 40(4): 975-980, 2006.

Kuehl, P. J., M. D. Carducci and P. B. Myrdal: 4-Imino-1,3-diazabicyclo[3.1.0]hexan-2-one.  Acta Cryst. E E62: o3688-o3690, 2006.

Kuehl, P. J., W. L. Hoye and P. B. Myrdal: Performulation Studies on Imexon.  Drug Dev. Ind. Pharm. 32(6): 687-697, 2006.

Myrdal, P. B., B. S. Angersbach, K. Karlage and P. J. Kuehl: Chiral Separation of Lipoxygenase Metabolites Utilizing High-Performance Liquid Chromatography.  Chromatogr. A 1132(1-2): 315-319, 2006.

2005

Benson JM, Hutt JA, Rein K, Boggs SE, Barr EB, Fleming LE. The toxicity of microcystin LR in mice following 7 days of inhalation exposure. Toxicon [Internet]. 2005 May [cited 2013 Oct 25];45(6):691–8. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2551753&tool=pmcentrez&rendertype=abstract

Benson JM, Stagner BB, Martin GK, Friedman M, Durr SE, Gomez AP, et al. Cochlear function in mice following inhalation of brevetoxin-3. J Comp Physiol A Neuroethol Sens Neural Behav Physiol [Internet]. 2005 Jul [cited 2013 Oct 25];191(7):619–26. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2652728&tool=pmcentrez&rendertype=abstract

Reed MD, Blair LF, Burling K, Daly I, Gigliotti AP, Gudi R, et al. Health effects of subchronic exposure to diesel-water emulsion emission. Inhal Toxicol [Internet]. 2005 Dec 15 [cited 2013 Oct 30];17(14):851–70. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16282163

2004

Benson JM, Hahn FF, March TH, McDonald JD, Sopori ML, Seagrave JC, et al. Inhalation toxicity of brevetoxin 3 in rats exposed for 5 days. J Toxicol Environ Health A [Internet]. 2004 Oct 24 [cited 2013 Oct 31];67(18):1443–56. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2846653&tool=pmcentrez&rendertype=abstract

Benson JM, Hahn FF, Tibbetts BM, Bowen LE, March TH, Langley RJ, et al. Florida red tide: Inhalation toxicity of Karenia breve extract in rats. In: Steidinger K, Landsberg J, Tomas C, Vargo G, editors. Harmful Algae 2002: Proceedings of the Xth International Conference on Harmful Algae. St. Pete Beach, FL: Florida Fish and Wildlife Conservation Commission; 2004. p. 502–4.

McDonald JD, Barr EB, White RK. Design, characterization and evaluation of a small-scale diesel exhaust exposure system. Aerosol Sci Technol. 2004;38(1):62–78.

McDonald JD, Barr EB, White RK, Chow JC, Schauer JJ, Zielinska B, et al. Generation and characterization of four dilutions of diesel engine exhaust for a subchronic inhalation study. Environ Sci Technol [Internet]. 2004 May 1 [cited 2013 Nov 1];38(9):2513–22. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15180045

McDonald JD, Bechtold WE, Krone JR, Blackwell WB, Kracko DA, Henderson RF. Analysis of butadiene urinary metabolites by liquid chromatography-triple quadrupole mass spectrometry. J Anal Toxicol [Internet]. 2004 Apr [cited 2013 Nov 1];28(3):168–73. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15107146

McDonald JD, Eide I, Seagrave JC, Zielinska B, Whitney KA, Lawson DR, et al. Relationship between composition and toxicity of motor vehicle emission samples. Environ Health Perspect [Internet]. 2004 Nov [cited 2013 Nov 1];112(15):1527–38. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1247617&tool=pmcentrez&rendertype=abstract

McDonald JD, Harrod KS, Seagrave JC, Seilkop SK, Mauderly JL. Effects of low sulfur fuel and a catalyzed particle trap on the composition and toxicity of diesel emissions. Environ Health Perspect [Internet]. 2004 Sep [cited 2013 Nov 1];112(13):1307–12. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1247521&tool=pmcentrez&rendertype=abstract

Reed MD, Gigliotti AP, McDonald JD, Seagrave JC, Seilkop SK, Mauderly JL. Health effects of subchronic exposure to environmental levels of diesel exhaust. Inhal Toxicol [Internet]. 2004 Apr [cited 2013 Nov 1];16(4):177–93. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15204765

2003

Barrett EG, Rudolph K, Bowen LE, Bice DE. Parental allergic status influences the risk of developing allergic sensitization and an asthmatic-like phenotype in canine offspring. Immunology [Internet]. 2003 Dec [cited 2013 Nov 4];110(4):493–500. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1783065&tool=pmcentrez&rendertype=abstract

Barrett EG, Rudolph K, Bowen LE, Muggenburg BA, Bice DE. Effect of inhaled ultrafine carbon particles on the allergic airway response in ragweed-sensitized dogs. Inhal Toxicol [Internet]. 2003 Feb [cited 2013 Nov 4];15(2):151–65. Available from: http://www.ncbi.nlm.nih.gov/pubmed/12528044

Singh SP, Barrett EG, Kalra R, Razani-Boroujerdi S, Langley RJ, Kurup VP, et al. Prenatal cigarette smoke decreases lung cAMP and increases airway hyperresponsiveness. Am J Respir Crit Care Med [Internet]. 2003 Aug 1 [cited 2013 Nov 5];168(3):342–7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/12791581

2002

Barrett EG, Wilder JA, March TH, Espindola T, Bice DE. Cigarette smoke-induced airway hyperresponsiveness is not dependent on elevated immunoglobulin and eosinophilic inflammation in a mouse model of allergic airway disease. Am J Respir Crit Care Med [Internet]. 2002 May 15 [cited 2013 Nov 5];165(10):1410–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/12016105

Bice DE, Barrett EG, Rudolph K. Insights from animal models of asthma. In: Heinrich U, Mohr U, editors. Crucial Issues in Inhalation Research. Stuttgart, Germany: Fraunhofer IRB Verlag; 2002. p. 127–49.

2001

Barrett EG, Bice DE. Cigarette smoke and allergic asthma: animal models. In: Watson R, Witten M, editors. Environmental tobacco Smoke. Boca Raton, FL: CRC Press; 2001. p. 337–48.